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A large group of marathon runners at the starting line, wearing colorful athletic gear and race bibs, competing in a long-distance endurance event.

Marathon Running Forces Your Brain to Use Its Own Reserves for Fuel

our brain primarily depends on glucose for energy while running. However, after hours of exertion, glucose reserves decline. To compensate, the brain shifts to lactate as an alternative fuel source. In extreme cases, when energy levels drop critically low, the brain may even start breaking down myelin for energy—a process known as metabolic plasticity in endurance athletes. This ability to switch fuel sources plays a crucial role in marathon training and brain health

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